Viral membrane fusion figure, from the Peter S. Kim Lab

Welcome to the Peter S. Kim Lab

We are interested in understanding the mechanism of viral membrane fusion and its inhibition by drugs and antibodies. The HIV envelope protein (gp120/gp41) serves as a model system. The ultimate goal is to create an HIV vaccine.

Publication Highlights

  1. Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates.
    Elisabetta Bianchi, Joseph G. Joyce, Michael D. Miller, Adam C. Finnefrock, Xiaoping Liang, Marco Finotto, Paolo Ingallinella, Philip McKenna, Michael Citron, Elizabeth Ottinger, Robert W. Hepler, Renee Hrin, Deborah Nahas, Chengwei Wu, David Montefiori, John W. Shiver, Antonella Pessi, and Peter S. Kim Proc. Natl. Acad. Sci. USA (2010) 107: 10655-10660. (PDF)
  2. Mechanisms of Viral Membrane Fusion and Its Inhibition.
    Debra M. Eckert and Peter S. Kim Annu. Rev. Biochem. (2001) 70: 777-810. (PDF)